{"id":62237,"date":"2024-09-13T10:39:28","date_gmt":"2024-09-13T17:39:28","guid":{"rendered":"http:\/\/www.todayifoundout.com\/?p=62237"},"modified":"2024-09-13T10:39:28","modified_gmt":"2024-09-13T17:39:28","slug":"does-leprosy-actually-make-your-fingers-and-toes-drop-off","status":"publish","type":"post","link":"https:\/\/www.todayifoundout.com\/index.php\/2024\/09\/does-leprosy-actually-make-your-fingers-and-toes-drop-off\/","title":{"rendered":"Does Leprosy Actually Make Your Fingers and Toes Drop Off?"},"content":{"rendered":"<div class=\"pf-content\"><p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><a href=\"http:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-62238\" src=\"http:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy-340x191.jpg\" alt=\"\" width=\"340\" height=\"191\" srcset=\"https:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy-340x191.jpg 340w, https:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy-640x360.jpg 640w, https:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy-768x432.jpg 768w, https:\/\/www.todayifoundout.com\/wp-content\/uploads\/2024\/09\/leprosy.jpg 1280w\" sizes=\"auto, (max-width: 340px) 100vw, 340px\" \/><\/a>If you were a pilgrim or other traveller during the Middle Ages, you would have faced a whole host of dangers on the road, from bandits and pirates to harsh weather to wolves in the forest. But the encounter you would have feared most was with ghostly figures standing at the side of the road, dressed in rags and shaking rattles or bells to warn of their approach. Covered in sores and missing fingers and toes, they would beg you for alms, which you might give them before hastily rushing off, covering your mouth and nose with your cloak lest you contract their horrible affliction. These wretched figures were the lepers, sufferers of the dreaded disease of leprosy. Occupying the lowest rung of the Medieval caste system, lepers were declared legally dead by the church and banished to the margins of society, forbidden to interact with the non-infected and forced to beg by the roadside. Such was the stigma associated with this disease that to this day, the term \u201cleper\u201d remains synonymous with social ostracism. But just what <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>is <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">leprosy, anyway? Is it really as contagious as Medieval people believed? Does it really make your fingers and toes drop off? And is it still around today? Let\u2019s find out as we dive into the fascinating history of one of <\/span><\/span><\/span><span style=\"font-size: small;\">humanity\u2019s<\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> most feared &#8211; and misunderstood &#8211; diseases.<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Just when leprosy first began to afflict humans is unknown. The term <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>leprosy, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">from the Greek <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>lepra <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">or \u201cscale,\u201d has been around since at least Biblical times, with Leviticus 13:9-33 describing the disease as:<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\">\u201c<span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Sometimes a skin disease will spread all over a person\u2019s body, covering the skin from head to foot. The priest must look at that person\u2019s whole body. If the priest sees that the skin disease covers the whole body and that it has turned all the skin white, the priest must announce that the person is clean. But if the skin is raw, that person is not clean. When the priest sees the raw skin, he must announce that the person is unclean. The raw skin is not clean. It is leprosy.\u201d<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">However, it is generally recognized by scholars that the biblical affliction <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Tzaraath, <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">often translated into English as \u201cleprosy\u201d refers not to the <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>physical <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">disease leprosy as we know it today but rather a <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>spiritual <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">condition brought about by ritual impurity, which could disfigure not only the human body but also clothing and walls or other surfaces in the home. And even if the term <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>does <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">refer to an actual disease, it is unclear whether this is actual leprosy or one of many other common skin diseases like eczema, psoriasis, vitiligo, or scleroderma. Similar descriptions in Ancient Egyptian and Ancient Indian texts are equally ambiguous.<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Whatever the case, the oldest confirmed case of actual leprosy dates from the 2nd millennium B.C.E., discovered in a skeleton unearthed in Balathal, Rajasthan, in 2009. The oldest case in the West was found in a skeleton unearthed that same year in Jerusalem, dating from the 1st Century C.E. Based on this and other DNA evidence, epidemiologists believe leprosy spread from the Indian subcontinent to Eurasia around the 4th Century B.C.E., possibly carried by the armies of Alexander the Great. By the 12th Century C.E., the disease was well-established &#8211; and widely feared in Europe &#8211; so much so that during the Third Lateran Council of 1179, the Catholic Church declared that sufferers must be banished &#8211; not only from regular society, from the realm of the living. Upon receiving a diagnosis, lepers were subjected to a bizarre ritual known as the \u201clepers\u2019 mass\u201d, wherein they were made to kneel in an open grave while a priest poured cemetery earth over their heads three times, symbolizing that they were now<\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i> \u201cDead unto the world but alive unto Christ.\u201d <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">The priest then read off a long list of prohibitions, condemning the leper to a life of ostracism and isolation:<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\">\u201c<span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>I forbid you to enter the church or monastery, fair, mill, market-place, or company of persons\u2026ever to leave your house without your leper\u2019s costume\u2026to wash your hands or anything about you in the stream or fountain. I forbid you to enter a tavern\u2026I forbid you, if you go on the road and you meet some person who speaks to you, to fail to put yourself downwind before you answer\u2026I forbid you to go into a narrow lane so that if you should meet anyone he might catch the affliction from you\u2026I forbid you ever to touch children or give them anything. I forbid you to eat or drink from any dishes but your own. I forbid you to eat or drink in company, unless with lepers.\u201d<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Lepers were also required to carry a bell or rattle to warn others of their arrival, could not be buried alongside the uninfected, and were limited to living in special hospitals or colonies called <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>leprosaria. <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">These were located well outside towns and cities, but always along a main road, for the only means available to lepers for earning a living was begging for alms to passers-by. But even this marginal existence was arguably better than the alternative, for in many places lepers were burned alive to prevent the disease from spreading. And while lepers could only lodge in leprosaria, there was no law confining them to the grounds, meaning they could roam at will so long as they followed the many rules previously outlined. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Strangely, while lepers were most often subjects of fear, they simultaneously occupied a unique position in Medieval spiritual life. Neither truly living nor yet dead, lepers were seen as serving out their time in purgatory here on earth. Thus, giving alms to lepers &#8211; often in exchange for their blessings &#8211; was believed to reduce one\u2019s own time in purgatory and was encouraged by the church. The association between Jesus and lepers &#8211; whom he healed in one of his many miracles &#8211; granted them further spiritual significance. They were, in a strange way, considered uniquely blessed by God.<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Examining the common symptoms of leprosy, it is easy to see why it has inspired such fear and revulsion. The first symptom of the disease is typically the appearance of stiff, dry, discoloured patches of skin all over the body, followed by the formation of thick skin nodules and ulcers which can cause horrible disfigurement. This is followed by muscle weakness, hair loss, and loss of sensation in the extremities &#8211; the latter of which results in the most famous symptom of leprosy: loss of fingers and toes. However, these digits do not actually \u201cdrop off\u201d as is commonly believed. Rather, loss of sensation makes leprosy sufferers more likely to accidentally injure themselves, leading to tissue loss and secondary infections that cause the body to reabsorb damaged cartilage &#8211; and the digits along with it. This phenomenon is also responsible for one of the other classic signs of leprosy: a collapsed or \u201csaddle\u201d nose caused by the reabsorption of nasal cartilage. If the nerve damage spreads to the eyelids, sufferers can become insensitive to dust and other foreign objects, resulting in corneal scratching and ulcers and eventually blindness. Meanwhile, leprosy can also slowly suffocate its victims as the nodules and ulcers block their nasal and throat passages &#8211; <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>lovely. <\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">In addition to being horrifying, leprosy was extremely common during the Middle Ages &#8211; an unusual fact, for reasons we will get to shortly. From 1100 onwards the disease spread like wildfire across Europe, such that by 1300 there were some 19,000 leprosaria across the continent. At its height, leprosy is thought to have infected up to 1% of the European population. But then, around 1400, cases of the disease fell precipitously &#8211; for reasons that are not yet fully understood. One theory is that extreme quarantine measures imposed by the Church actually worked, causing transmission rates to plummet and natural immunity to the disease to spread through the population. Another theory credits the spread of tuberculosis across Europe during this period. Indeed, the causative agents of both diseases are very similar, and infection with one is thought to confer immunity to the other. But the most common &#8211; and darkest &#8211; explanation has to do with an even more famous disease that swept through Europe in the mid-14th century: the Bubonic Plague or <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Black Death. <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Leprosy sufferers, with their already weakened immune systems, would have been particularly vulnerable, causing most of them to be wiped out. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">For much of history, Leprosy was thought to be either inflicted by God, caused by <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>miasma <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">or \u201cbad air,\u201d or a congenital condition passed down through families. In 1873, however, Norwegian physician Gerhard Armauer Hansen discovered that the disease was actually caused by the microorganism <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Mycobacterium leprae. <\/i><\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">It was the first time in history a bacterium was definitively linked with human disease. In honour of this discovery &#8211; and to combat the stigma associated with the disease &#8211; today leprosy is most often referred to as <\/span><\/span><\/span><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Hansen\u2019s Disease.<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Yet despite such breakthroughs, the stigmatization and banishment of leprosy sufferers remained commonplace. Perhaps the most famous contemporary example of this practice took place in Hawaii, where leprosy first arrived in 1866. That same year, the Hawaiian legislature passed a law declaring that lepers would be declared legally dead and banished to a remote colony on the island of Moloka\u2019i. While the colony was meant to be self-sustaining, the residents\u2019 advanced illnesses often prevented them from farming productively, leaving them on the brink of starvation. In 1874, Bishop Louis Maigret of the the Catholic Archdiocese of Honolulu asked for volunteers to help improve conditions on Moloka\u2019i. Four priests volunteered, and one was selected: Belgian-born Joseph de Veuster, better known as Father Damien.<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #121212;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">On arriving at the Moloka\u2019i colony, Father Damien was shocked at the squalid living conditions, which he described in an 1886 report to the Board of Health: <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\">\u201c<span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>The smell of their filth, mixed with the exhalation of their sores, was simply disgusting and unbearable to a newcomer. Many a time in fulfilling my priestly duties at their domiciles, I have been compelled not only to close my nostrils, but to run outside and breathe the fresh air\u2026At that time the progress of the disease was fearful, and age rate of mortality very high. In previous years, having nothing but small, damp huts, nearly the whole of the lepers were prostrated on their beds, covered with scabs and ugly sores, and had the appearance of very weak, broken-down constitutions.\u201d<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Despite these challenging conditions, Father Damien remained at the colony for the next 15 years, working with native Hawaiian superintendent William P. Ragsdale to improve living conditions by building and maintaining homes, hospitals, orphanages, churches, schools, and other amenities. Throughout his tenure, Damien ignored common wisdom regarding the transmission of leprosy, freely sharing food and his pipe with the colony residents in order to gain their trust. Alas, it was to prove his undoing, for one day in 1884 he accidentally put his foot in scalding water and realized he felt nothing. He had contracted leprosy. Undeterred, Damien continued to serve the Moloka\u2019i colony, his condition gradually worsening until, on April 15, 1889, he finally succumbed to the disease at the age of 59. It was an eerily fitting end, for in 1874 Bishop Maigret had introduced him to the colony with the words:<\/span><\/span><\/span><\/p>\n<p align=\"CENTER\"><span style=\"color: #000000;\">\u201c<span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Here is Father Damien, who wishes to sacrifice himself for the salvation of your souls.\u201d<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Following his death, Father Damien\u2019s legacy was savagely attacked by Presbyterian minister Reverend Charles McEwen Hyde, who blamed Damien\u2019s death on his own carelessness and accused him of taking credit for measures originated by the Hawaiian Board of Health. To Damien\u2019s defence came no less a figure than Scottish author Robert Louis Stevenson, who travelled to Hawaii in 1886 seeking a cure for his tuberculosis and interviewed several residents of the Moloka\u2019i colony. In a written rebuttal to Reverend Hyde, Stevenson concluded that:<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #1f2021;\">\u201c<span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>[Their testimonies] build up the image of a man, with all his weakness, essentially heroic, and alive with rugged honesty, generosity, and mirth.\u201d<\/i><\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">100 years later, Father Damien\u2019s service and sacrifice were recognized when, in 1995, he was beatified by Pope John Paul II. In 2009, he was canonized by Pope Benedict XVI as Saint Damien of Moloka\u2019i, patron saint of &#8211; who else &#8211; lepers. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Incredibly, the Moloka\u2019i leper colony did not close until 1969, having been home to nearly 8,000 people over its 103 year history. The only leprosarium in the mainland United States lasted even longer. Located in Carville, Louisiana, the facility was established in 1894 on the site of an abandoned sugar plantation and operated by the Daughters of Charity of St. Vincent de Paul until 1905, when the hospital was taken over by the state of Louisiana. In 1921, administration transferred to the US Public Health Service, who renamed the facility the National Leprosarium. As in earlier periods of history, life for the patients was extremely restricted. They were not allowed to vote, marry, or live with their spouses if they were not also patients. However, things began to change in the 1930s when a patient named Stanely Stein founded a magazine called <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>The Star<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">, which he used to advocate for the improved treatment of leprosy sufferers. Stein soon found a supporter in Hollywood actress Tallulah Bankhead, who convinced many of her friends to buy subscriptions to The Star and even sent Stein a cast of her face when leprosy eventually blinded him. Thanks to Stein and Bankhead\u2019s tireless advocacy, many of the draconian restrictions at Carville were lifted and the medical community began to adopt the term \u201cHansen\u2019s Disease\u201d over \u201cleprosy.\u201d Still the Carville Leprosarium persisted, until in 1999 the State of Louisiana gave the few remaining patients the option to leave in exchange for a $46,000 annual stipend. Some still chose to stay, with the last residents only leaving Carville in 2015. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Sadly, however, leprosaria are still not a thing of the past, with the practice of stigmatizing and ostracizing leprosy sufferers persisting in China, Thailand, and several African countries, and India, where there are still more than a thousand leper colonies still in existence. What makes this all the more tragic is that of all major human diseases, leprosy is now known to be the <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>least <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">transmissible, with 95% of the human population being naturally immune. And even if someone <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>is<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> susceptible, it takes prolonged, close contact with a sufferer &#8211; more specifically, infected droplets in their breath &#8211; to become infected, which is why it took 11 years living on Moloka\u2019i for Father Damien to catch the disease. And once someone is infected, it can take up to 20 years for symptoms to appear. This makes the rapid spread of the disease during the Middle Ages particularly mysterious. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Also making the continued stigmatization of leprosy especially tragic is the fact that the disease is now treatable and even curable. But this was not always the case, with traditional remedies for leprosy including drinking the blood of various animals, administering the venom of scorpions and snakes, and elaborate spiritual purification rituals as detailed in Leviticus. Later, due to the similarity of its skin lesions, doctors attempted to treat leprosy in the same manner as syphilis: using highly toxic mercury. For most of human history, the only truly effective treatment for leprosy was Chaulmoogra Oil, derived from <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Hydnocarpus wightianus<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> tree native to India. Unfortunately, the oil caused severe nausea when administered orally and painful abscesses when injected, meaning it was typically administered topically &#8211; the least effective delivery method. But in 1915 Alice Ball, the first black woman to obtain a Master\u2019s in Chemistry from the University of Hawaii, discovered how to create an ethyl ester of Chaulmoogra Oil that was water-soluble, allowing it to be safely delivered via intramuscular injection. This discovery revolutionized the treatment of leprosy in Hawaii and around the world, and so impressed Ball\u2019s professors that she was invited to teach chemistry at the University &#8211; the first black woman to do so. Tragically, Alice Ball would not live to see the fruits of her accomplishments. In March 1916, while giving a demonstration on the proper use of a gas mask, Ball accidentally inhaled a lungful of chlorine gas. She was sent to the mainland for treatment and returned in the fall to resume teaching, but the damage was too severe and she died on December 31, 1916 at the age of only 24. Credit for her discoveries was stolen by fellow chemist Arthur L. Dean, who named the the ester of Chaulmoogra Oil after himself and began mass-producing it. It was not until recently that Alice Ball\u2019s contributions were finally recognized and her leprosy treatment renamed the \u201cBall Method.\u201d<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">The Ball Method remained the standard treatment for leprosy until the 1940s, when it was replaced by the antibiotic diaminodiphenyl sulfone, better known as <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Dapsone. <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">But while far more effective than Chaulmoogra Oil, Dapsone could not fully eliminate leprosy from a patient\u2019s system, and thus had to be taken for life in order to keep the infection at bay. Worse still, by the 1960s the <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>M. Leprae<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> bacterium had begun developing resistance to Dapsone. As a result, the drug was combined with two other antibiotics &#8211; rifampicin and clofazimine &#8211; to create a potent multi-drug treatment or \u201ccocktail\u201d that can completely cure leprosy in six months and remains the standard treatment to this day. Also sometimes used is a drug with an infamous past: Thalidomide. Introduced in 1957, Thalidomide was originally sold over-the-counter to pregnant women as a treatment for morning sickness, but was eventually found to cause severe birth defects, causing it to be be pulled from shelves. However, in 1964, Israeli physician Jacob Sheskin administered thalidomide to a patient with severe leprosy and noted a significant effect on skin lesions. Due to its immune-modulating properties, thalidomide is also used in the treatment of cancers such as multiple myeloma and graft-vs.-host disease.<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">In the early 1980s, the World Health Organization launched a campaign to eradicate leprosy worldwide. By the year 2000, it succeeded in eliminating the disease as a public health concern &#8211; defined as less than 1 case per 10,000 people. However, leprosy still persists in certain regions, and is currently classified as a Neglected Tropical Disease by the WHO. Indeed, around 250,000 people contract the disease every year, with around half of those living in India. And in many places, even those who are cured still face stigma and ostracism due to the permanent disfigurement and nerve damage wrought by the disease. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">While leprosy is largely a human disease, it has been found in other animals, including &#8211; strangely &#8211; nine-banded armadillos, whose body temperature of 32 degrees Celsius is ideal for the growth of <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>M. Leprae. <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">As leprosy did not exist in the Americas until the arrival of Europeans, the armadillos must have caught it from humans &#8211; a reversal of the typical transmission path for zoonotic diseases. Thankfully, however, the incubation period for leprosy is typically longer than the armadillos\u2019 lifespan, meaning they rarely suffer from the effects of the disease. Leprosy has also been found in nonhuman primates such as chimpanzees and the cynomolgus macaque, and in European red squirrels. Indeed, DNA evidence from a pre-Norman Anglo-Saxon skull excavated in Hoxne, Suffolk in 2017 suggests that leprosy may have been transmitted to the British Isles via the trade in squirrel pelts and meat between the Saxons and the Vikings. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">And this most misunderstood of diseases continues to offer up new surprises &#8211; including the unique ability to alter its hosts\u2019 tissues to suit its own needs. In 2013, a team of biologists from the University of Edinburgh discovered that <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>M. Leprae <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">can genetically reprogram the cells of Armadillos to turn them back into undifferentiated stem cells. These can then be turned into whatever cells the bacterium needs to grow. For example, in one case <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>M. Leprae <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">grew its host\u2019s liver to twice its normal size without it becoming cancerous or otherwise defective. The implications of this discovery are enormous, and could potentially lead to a whole new era of gene therapies to repair damaged organs. It seems the Medieval priests were right after all: leprosy <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>is <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">a strange sort of blessing. <\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span class=\"collapseomatic \" id=\"id69f213157c2e9\"  tabindex=\"0\" title=\"Expand for References\"    >Expand for References<\/span><div id=\"target-id69f213157c2e9\" class=\"collapseomatic_content \">\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Kang, Lydia &amp; Pedersen, Nate,<\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i> Patient Zero: a Curious History of the World\u2019s Worst Diseases, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Workman Publishing, New York, 2021<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Strathern, Paul, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>A Brief History of Medicine,<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> Constable &amp; Robinson Ltd, London, 2005<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>What is Hansen\u2019s Disease?<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> Centers for Disease Control and Prevention, <\/span><\/span><\/span><a href=\"https:\/\/www.cdc.gov\/leprosy\/about\/about.html\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.cdc.gov\/leprosy\/about\/about.html<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">MacPherson, Hamish, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Dr. Isabel Kerr: the Scots Doctor Who Pioneered Treatment for Leprosy in India, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">The National, January 11, 2021, <\/span><\/span><\/span><a href=\"https:\/\/www.thenational.scot\/news\/19000081.scots-doctor-pioneered-treatment-leprosy-india\/\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.thenational.scot\/news\/19000081.scots-doctor-pioneered-treatment-leprosy-india\/<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Mendheim, Beverly,<\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i> Lost and Found: Alice Augusta Ball, an Extraordinary Woman of Hawai\u2019i Nei, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Northwest Hawai\u2019i Times, September 2007, <\/span><\/span><\/span><a href=\"https:\/\/web.archive.org\/web\/20160303233106\/http:\/\/www.northwesthawaiitimes.com\/hnsept07.htm\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/web.archive.org\/web\/20160303233106\/http:\/\/www.northwesthawaiitimes.com\/hnsept07.htm<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Leprosy, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">World Health Organization, January 27, 2023, https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/leprosy<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Walsh, Fergus, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>The Hidden Suffering of India\u2019s Lepers, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">BBC News, March 31, 2007, <\/span><\/span><\/span><a href=\"http:\/\/news.bbc.co.uk\/2\/hi\/programmes\/from_our_own_correspondent\/6510503.stm\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>http:\/\/news.bbc.co.uk\/2\/hi\/programmes\/from_our_own_correspondent\/6510503.stm<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Ee Lyn, Tan,<\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i> Ignorance Breeds Leper Colonies in China, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">IOL, September 13, 2006, <\/span><\/span><\/span><a href=\"https:\/\/web.archive.org\/web\/20100408075048\/http:\/\/www.iol.co.za\/index.php?set_id=1&amp;click_id=117&amp;art_id=qw1158139440409B243\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/web.archive.org\/web\/20100408075048\/http:\/\/www.iol.co.za\/index.php?set_id=1&amp;click_id=117&amp;art_id=qw1158139440409B243<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Could Squirrel Fur Trade Have Contributed to England\u2019s Medieval Leprosy Outbreak? <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Science Daily, October 25, 2017, https:\/\/www.sciencedaily.com\/releases\/2017\/10\/171025103109.htm<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Wong, Kathleen, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>The Trailblazing Black Woman Chemist Who Discovered a Treatment for Leprosy, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Smithsonian Magazine, March 23, 2022, <\/span><\/span><\/span><a href=\"https:\/\/www.smithsonianmag.com\/history\/the-trailblazing-black-woman-chemist-who-discovered-a-treatment-for-leprosy-180979772\/\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.smithsonianmag.com\/history\/the-trailblazing-black-woman-chemist-who-discovered-a-treatment-for-leprosy-180979772\/<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Shurpin, Yehuda, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Is Tzaraat Leprosy? <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Chabad, <\/span><\/span><\/span><a href=\"https:\/\/www.chabad.org\/library\/article_cdo\/aid\/4714280\/jewish\/Is-Tzaraat-Leprosy.htm\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.chabad.org\/library\/article_cdo\/aid\/4714280\/jewish\/Is-Tzaraat-Leprosy.htm<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Medieval Leprosy,<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> Intriguing History, April 24, 2017, https:\/\/intriguing-history.com\/medieval-leprosy\/<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Jarry, Jonathan, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Leprosy and its Stigma are Both Curable,<\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"> McGill University Office for Science and Society, November 6, 2021, <\/span><\/span><\/span><a href=\"https:\/\/www.mcgill.ca\/oss\/article\/health-and-nutrition-history\/leprosy-and-its-stigma-are-both-curable\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.mcgill.ca\/oss\/article\/health-and-nutrition-history\/leprosy-and-its-stigma-are-both-curable<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Gallagher, James, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i>Leprosy Bacteria use \u201cBiological Alchemy\u201d, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">BBC News, January 18, 2013, <\/span><\/span><\/span><a href=\"https:\/\/www.bbc.com\/news\/health-21056644\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><u>https:\/\/www.bbc.com\/news\/health-21056644<\/u><\/span><\/span><\/span><\/a><\/p>\n<p align=\"LEFT\"><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">Gallagher, James,<\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\"><i> Leprosy: Ancient Disease Able to Regenerate Organs, <\/i><\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Times New Roman, serif;\"><span style=\"font-size: small;\">BBC News, November 15, 2022, https:\/\/www.bbc.com\/news\/health-63626239<\/span><\/span><\/span><\/p>\n<p align=\"LEFT\"><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>If you were a pilgrim or other traveller during the Middle Ages, you would have faced a whole host of dangers on the road, from bandits and pirates to harsh weather to wolves in the forest. But the encounter you would have feared most was with ghostly figures standing at the side of the road, dressed in rags and shaking [&#8230;]<\/p>\n","protected":false},"author":188,"featured_media":62238,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,10],"tags":[],"class_list":["post-62237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-today-i-found-out","category-science"],"_links":{"self":[{"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/posts\/62237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/users\/188"}],"replies":[{"embeddable":true,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/comments?post=62237"}],"version-history":[{"count":1,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/posts\/62237\/revisions"}],"predecessor-version":[{"id":62239,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/posts\/62237\/revisions\/62239"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/media\/62238"}],"wp:attachment":[{"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/media?parent=62237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/categories?post=62237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.todayifoundout.com\/index.php\/wp-json\/wp\/v2\/tags?post=62237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}